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Human truncated thioredoxin (Trx80) as a novel mitogenic cytokine for white blood cells
(2001-11-27)
Thioredoxin (Trx) is a 12 kDa protein present in all species with a well-conserved active site sequence comprising -Cys-Gly-Pro-Cys-, which catalyzes oxido-reductase reactions. Trx regulates the activity of transcription ...
Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1
(2009-03-27)
MAML1 was first identified as a coactivator for Notch receptors, but later it was also found to function as a coactivator for several other activators, including p53, beta-catenin, and MEF2C. MAML1 is critical for Notch ...
Studies on the activation of cytosolic phospholipase A2 and 15-lipoxygenase-1 in hematopoietic cells
(2009-04-08)
Arachidonic acid is a polyunsaturated fatty acid that has four double bonds and belongs to the omega-6 family of fatty acids. Although it can be formed in humans from one essential fatty acid (linoleic acid), most of the ...
Therapeutic response in human cancers : the dual role of STAT signalling
(2016-08-08)
STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects ...