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Cholesterol turnover in acute myelogenous leukemia with special emphasis on regulation of low density lipoprotein receptor expression in leukemic cells
(2001-10-26)
Cellular cholesterol requirements are met by receptor mediated uptake of cholesterol in low density lipoprotein (LDL) particles and/or by endogenous synthesis, the rate limiting enzyme in the synthesis pathway being ...
Bereavement in adulthood and risks of incident and recurrent cardiovascular diseases
(2022-04-29)
Bereavement, the loss of a family member or a loved one, is a severely stressful life event that may occur at least once in most individuals’ life. Bereaved persons are likely to be influenced by the loss in multiple aspects ...
Hypoxia-inducible factor-1 (HIF-1) in pancreatic cancer cell aggressiveness and therapeutic resistance and the potential role for pancreatic endocrine cells in islet transplantation
(2013-12-20)
Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic functions in various tissues, including both normal and malignant. It is known that a heterodimeric transcription factor hypoxia-inducible ...
Molecular basis of L-DOPA-induced dyskinesia : studies on striatal signaling
(2009-08-28)
Parkinson s disease (PD) is a neurological disorder characterized by tremor, rigidity and bradykinesia. PD is caused by selective degeneration of the dopaminergic neurons, which originate in the substantia nigra pars ...
Targeting chronic lymphocytic leukemia cells using anti-ROR1 monoclonal antibodies and small molecules inhibitors
(2015-04-29)
Chronic lymphocytic leukemia (CLL) is characterized by accumulation of malignant B cells in blood,
bone marrow, spleen and lymph nodes. It is the most common leukemia in the Western world. Major
progress has been made ...