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Hereditary breast/ovarian cancer : implementation of BRCA1 and BRCA2 testing
(2001-05-02)
Breast cancer is the most common malignancy among women in the western
world. Most cases are sporadic but in 5 to 10 % an inherited genetic
mutation is the main cause of the disease. Families with inherited breast
cancer ...
Localization and characterization of genes involved in parathyroid tumor development
(2003-03-21)
The overall goal of this thesis has been to identify new genes and characterize them regarding the involvement in parathyroid tumor development. The parathyroid glands are responsible for the control of calcium homeostasis. ...
Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
It has been almost 30 years since the identification of HIV as the causative agent of AIDS. Despite considerable efforts to halt the spread of the virus, the epidemic continues in many parts of the world. The most efficient ...
The impact of airway-irritating exposure and wet work on subjects with allergy or other sensitivity : epidemiology and mechanisms
(2007-09-14)
The prevalence of asthma and allergies is increasing, which means that
the proportion of workers on the labour market with allergy or other
sensitivity also increases. It is as of yet not known to what extent
these ...
Potential mechanisms for acute health effects and lung retention of inhaled particles of different origin
(2012-05-11)
Background: Environmental particle exposure is known to have negative health effects. There is limited knowledge about how size and origin of particles influence these effects. There is also little known regarding the fate ...
Genetic and functional studies on the thyroid hormone axis
(2008-10-24)
This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. The second is about gaining ...
Systemic stress response and hyperglycemia after abdominal surgery in rat and man
(2008-10-23)
Surgical trauma results in a complex neuroendocrine and metabolic response known as the systemic stress response, which is initiated by neuronal and humoral signals from the site of the injury. These signals converge at ...
Linking innate and adaptive immunity to streptococcus pneumoniae
(2012-09-05)
Streptococcus pneumoniae (the pneumococcus) most commonly colonizes the human nasopharyngeal mucosa without causing any symptoms. However, this organism has the potential to spread to normally sterile sites and cause ...
Congenital cataract and contact lenses
(2022-03-29)
Purpose: Having a child with congenital cataract is associated with a huge responsibility for the parents in terms of the outcome of their child’s visual development. If the cataract is not removed the condition will lead ...
Cardiovascular risk factors in children
(2005-02-04)
Non-communicable diseases, above all cardiovascular disease (CVD), are the most common causes of morbidity and mortality in Europe. CVD has been shown to have its roots in childhood, although the clinical manifestations ...