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Mithochondrial function in human skeletal muscle : with special reference to exercise and training
(2000-09-15)
The overall objective of this thesis was to study the adaptation of oxidative function in human skeletal muscle to acute exercise of different modes, intensities and durations, and to endurance training.
The effects ...
Investigation of tumour/stroma crosstalk in pancreatic cancer by an advanced 3D co-culture model
(2022-06-01)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies all over the world. This dire situation is mainly attributable to the dense desmoplasia in the tumour microenvironment (TME) and almost complete ...
Modulation of cytochrome c release by mitochondrial redox status and caspase-2
(2005-03-25)
The release of cytochrome c is an important event during apoptosis, induced by diverse stimuli. Our laboratory has previously proposed that cytochrome c release occurs via a two-step process, involving the detachment of ...
DNA damage-induced cell death : the role of caspase-2
(2009-01-02)
Activation of a family of cysteine proteases, called caspases, is an
important event during apoptosis. In comparison to other caspases, less
is known about regulatory functions of caspase-2. Previous studies from
our ...