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Modulation of the deubiquitnating system during lymphoid cell activation and viral infection
(2005-08-15)
The family of ubiquitin-specific proteases (USPs) removes ubiquitin from its conjugates and regulates the production and recycling of ubiquitin. USPs are thereby critically involved in the control of important functions ...
Immunometabolic network interactions of the kynurenine pathway in cutaneous malignant melanoma
(2020-05-26)
Cancer is the second leading cause of mortality worldwide, and melanoma represents the most aggressive and deadliest form of skin cancer. Despite the various therapeutic approaches, metastatic melanoma is a disease with a ...
Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation
(2018-05-30)
The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, ...
Severe psychological stress associated with a cancer diagnosis
(2018-10-04)
Receiving a cancer diagnosis leads to severe psychological distress. Previous studies have shown increased risk for various health consequences following a cancer diagnosis, including mental disorders, life-threatening ...
Search for genetic determinants of Plasmodium falciparum malaria drug resistance in vitro and in vivo
(2014-11-27)
Malaria remains the most deadly disease in the world with nearly 627 000 deaths and more
than 200 million new clinical cases every year, the large majority occurring in sub Saharan
Africa children aged < 5 years. ...