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Epidemiological perspectives on sleep : health-related outcomes and subjective-objective sleep assessments
(2014-09-11)
This thesis aimed to expand knowledge about self-reported habitual sleep in relation to health outcomes and objectively measured sleep.
Study I was a cross-sectional analysis of 40,197 Swedish adult volunteers ...
Human embryonic stem cells : a novel model system for early human development
(2006-05-12)
Human embryonic stem cells (HESC) have since their first description in 1998 been recognized as a theoretically endless source of cells capable of differentiation into any somatic cell type. Although great attention has ...
Understanding inflammatory mechanisms in rheumatic diseases
(2014-11-05)
Rheumatoid arthritis (RA), Psoriasis (Ps) and Psoriasis arthritis (PsA) are chronic inflammatory autoimmune disorders, where primary targets are peripheral joints, skin and skin/joints respectively. Both innate and adaptive ...
Bilateral hearing aids for bilaterally hearing-impaired persons : always the best choice?
(2007-01-05)
The most logical solution if a person has a hearing impairment on both
ears, seems to be bilateral bearing aid amplification in both ears.
Numerous studies have shown the advantages of this fitting strategy.
However, ...
Molecular mechanisms of transcriptional repression by the orphan receptor SHP
(2005-02-18)
SHP (Small Heterodimer Partner) is an atypical orphan member of the mammalian nuclear receptor family that consists of only a putative ligand-binding domain and thus cannot bind DNA. The aim of this thesis was to investigate ...
Genomic clues to secondary injury mechanisms in brain trauma
(2006-09-01)
Traumatic brain injury (TBI) is a heterogenous disease that can lead to persistent disability or death. The immediate mechanical disruption of brain tissue is followed by a phase of secondary brain injury. During this phase ...
B cell fate following immunization : from memory B cells to plasma cells
(2017-04-21)
Most approved successful human vaccines induce neutralizing antibody titers maintained above a given threshold for long-term protection against potential pathogen exposure. The pathogens targeted by these vaccines are ...
Molecular genetic studies of colorectal cancer
(2005-09-23)
Colorectal cancer (CRC) is one of the leading causes of morbidity and mortality due to cancer in the Western countries. Epidemiological studies have shown that at least 20-30% of CRCs have a potentially identifiable genetic ...