Search
Now showing items 1-5 of 5
Genetic studies of congenital upper limb anomalies
(2014-03-03)
The overall aim of the work reported in this thesis is to improve epidemiological and genetic knowledge of congenital upper limb anomalies (CULA). To accomplish the specific aims of each paper several different methods and ...
Studies on the gamma-secretase complex and processing of the Alzheimer's disease-associated amyloid precursor protein
(2004-03-26)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that
causes the most common form of dementia. Pathological lesions, such as
plaques consisting of the amyloid beta-peptide (Ab), are found in the
brains ...
Optimization of pediatrics antiretroviral treatment outcomes among HIV infected children in Ethiopia
(2019-12-11)
Ending the HIV/AIDS epidemic by 2030 is a global agenda. To meet this global goal, having safe and effective antiretroviral therapy is a key requirement. In Ethiopia, the safety and efficacy of combination antiretroviral ...
Molecular characteristics of HIV-1 subtype C and its impact on therapeutic outcome in Ethiopia
(2018-07-26)
HIV-1 is characterized by a high genetic diversity which poses several challenges and implications with regard to disease progression, drug resistance and outcome of antiretroviral therapy (ART). HIV-1 subtype C (HIV-1C) ...
Antiretroviral treatment outcome and molecular epidemiology of HIV-1 subtype C drug resistance in Ethiopia
(2018-08-06)
Over the last decade, antiretroviral therapy (ART) has been rolled out in Ethiopia at a large scale. However, the outcome and aspects of drug resistance have been poorly studied at the national level. Also, the epidemic ...