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Provoked vestibulodynia : studies on pain genetics and pain co-morbidity
(2014-01-15)
Objective: The purpose of this thesis was to investigate a possible genetic predisposition for developing provoked vestibulodynia (PVD), focusing on previously defined single nucleotide polymorphisms (SNPs) in three genes ...
Ah receptor mediated toxicity : studies in vitro and in a transgenic mouse model
(2007-02-01)
The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to ...
Studies on gender-specific disruption of bone tissue homeostasis by dioxins
(2009-12-25)
Dioxins are widespread environmental pollutants, known to cause immunosuppression, developmental and reproductive defects, as well as cancer. The toxic effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR, ...
Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model
(2003-02-13)
The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and ...
The microbiome, PPARγ and AhR in the inflammation-metabolism interface within the gastrointestinal tract
(2014-04-04)
The mammalian body is a mosaic of different organisms - a holobiont, which contains all the biomolecules and their metabolites encoded in our eukaryotic genome and supplemented by an even larger pool of prokaryotic genes ...
Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli
(2010-03-26)
Cells have to sense and adapt to changes in their surrounding environment. Most of the cellular responses to environmental and developmental stimuli are mediated by PAS (Per-ARNT-Sim) proteins. A member of this family of ...