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Polycystic ovary syndrome and maternal obesity : does it programme transgenerational dysfunction?
(2024-01-08)
As one of the most prevalent syndromes among reproductive-aged women, polycystic ovary syndrome (PCOS) manifests with endocrine, reproductive and metabolic disturbances. However, the etiology of PCOS is yet to be fully ...
Single-cell transcriptomic analyses of early embryonic development and developmental programming by androgen excess
(2022-08-18)
Infertility is a compelling problem an increased prevalence among couples. Although multiple causes have been hypothesized to increase the risk of infertility, changes in lifestyles and environment are the possible links ...
Clinical presentation and outcomes of COVID-19 compared with other respiratory virus infections and hospital populations
(2022-10-14)
As of September 2022, more than 600 million cases of coronavirus disease 2019 (COVID-19) and 6.5 million deaths have been officially reported to the World Health Organization (WHO). The unfolding pandemic has exerted ...
Inference of systems-level behaviors in the immune system from single-cell data
(2020-03-27)
Understanding the systems-level behaviours of the immune system requires profiling many parameters of its constituents as well as identifying environmental factors influencing the time evolution of immune response. Recent ...
Cell states along oligodendrocyte development and disease
(2020-12-23)
The brain, one of the most complex organs in the body, where an immense diversity of cell states emerges from simple structure, where function arises from sets of regulatory principles and pattern persist where individual ...
At the intersection of proteomics and pathology : application of mass spectrometry-based protein quantification to histopathology and antibody validation
(2021-11-19)
The paradigm of Precision Medicine relies on the molecular stratification of patients to select “the right patient for the right drug”. The genomic approach has tried to answer this question, but large genomic studies have ...
Investigating adipose tissue turnover in humans using radiocarbon dating
(2020-12-28)
Obesity, defined as an excessive accumulation of body fat, is considered one of the major health challenges facing the world today. Adipocyte and lipid turnover determine the number and the size of fat cells, respectively. ...
The development of the human immune system during the first five years of life
(2019-05-24)
Systems immunology is a scientific field combining high-throughput analytic technologies and integrative data analysis to study the immune system from a holistic perspective. As the immune system is a complex integrated ...
Gene regulatory mechanisms in the oligodendrocyte lineage in development and disease
(2022-05-12)
Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They contribute to the neuronal network through the insulation of neuronal axons, facilitating communication between neurons and providing ...
Selection of the principal cause of death : studies on the basis of mortality statistics for rheumatoid arthritis
(1985-02-12)
The official statistics of Sweden for 1971-75 show a 2.7-fold increase in mortality for men and a 3.0-fold increase for women attributed to rheumatoid arthritis (RA) as the underlying cause of death. In order to investigate ...