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Mechanistic study of antiangiogenic agents in cancer therapy
(2013-05-17)
Tumor growth and metastasis are dependent on angiogenesis that constantly alters the tumor microenvironment. Based on the antiangiogenic principle proposed more than 40 years ago by Dr. Judah Folkman, antiangiogenic drugs ...
Escaping the riptide : probing the malleability of cognition
(2022-05-25)
Cognitive abilities are essential for functioning in daily life – even something as mundane as going to the grocery store taps into a variety of cognitive functions. Exactly how and under what circumstances they can be ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Applied bioinformatics for gene characterization
(2006-08-10)
As the vast majority of human protein-encoding genes are now identified, the new challenge placed before life scientists is the determination of the functions of the proteins. Traditionally, intense, directed efforts are ...
Mitochondrial DNA mutations : brain developmental and ageing consequences, and possible treatments
(2012-09-06)
Ageing is a complex process that involves cellular senescence, a gradual loss of tissue homeostasis, and decline in organ function. Abundant evidence implicates mitochondria in ageing suggesting: (i) accumulation of ...