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Pregnancy in Ro/SSA positive women
(2013-05-14)
Congenital heart block (CHB) may develop in the fetus during pregnancy in Ro/SSA positive women. It is a rare but life-threatening disease and the most serious manifestation of neonatal lupus erythematosus (NLE). The ...
Leukemia inhibitor factor (LIF) and gp130 in early defence against HIV-1 infection
(2006-11-23)
Leukemia inhibitor factor (LIF) is a polyfunctional cytokine that belongs to the IL-6 family which mainly signals through the Jak/Stat pathway via the gp130/LIFR-α heterodimer.
The focus of my research has been to ...
Epidermal stem cells at the point of no return
(2023-05-17)
The skin is our main barrier against outside harm, and it helps to maintain internal
homeostasis. These functions are mostly fulfilled by the epidermis, which is the
outermost layer of the skin, formed from keratinocytes ...
Single-cell analysis of mammalian cardiogenesis elucidating an essential role of outflow tract progenitors
(2021-09-14)
The heart is the first organ to form and start to function during mammalian embryogenesis. This complex organ system is constructed by a diverse set of cell types, involving mesodermal precursors and heart progenitors, at ...
Scarring and regeneration in the central nervous system
(2021-11-12)
In response to injury, tissues employ conserved reparative mechanisms to heal the damage and recover their function. The reparative success varies according to the organism, the tissue or organ, and the age of the specimen. ...
Extracellular factors for preservation and delivery of stromal cells
(2021-11-19)
Modulating the immune response after a myocardial infarction seems like an appropriate strategy for reducing myocardial fibrosis. Mesenchymal Stromal Cells are immunomodulatory and have thus gained interest, but have so ...
Dopamine : a versatile player in development, regeneration and disease
(2018-03-06)
The dopamine neurotransmitter is present in all multicellular organisms. In the brain, the dopaminergic system orchestrates reward-motivation pathways and is involved in the control of voluntary movements and endocrine ...
Molecular mechanisms of salamander limb regeneration
(2018-09-21)
Salamanders, like newts and axolotls, stand out among adult vertebrates for their outstanding capacity to regenerate whole body parts and restore complex structures upon injury. One of the best-known examples is their ...