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Antiretroviral drug resistant HIV-1 in women and children living in Honduras
(2013-02-15)
Antiretroviral therapy (ART) in HIV infected pregnant women contributes to the prevention of HIV transmission to the newborn. However, as ART can also induce HIV drug resistance during suboptimal levels of virological ...
Studies on the role of HIF-1 in the control of infection with Mycobacterium tuberculosis
(2022-12-21)
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), is responsible for most deaths caused by a bacterium globally. Two main reasons for this are that (Bacille Calmette–Guérin) BCG, the ...
Studies on pathogenesis, clinical features and comorbidities of idiopathic inflammatory myopathies
(2020-10-28)
Idiopathic inflammatory myopathies (IIM), a group of rare chronic inflammatory disorders, are characterized by a broad spectrum of clinical manifestations with high morbidity and mortality. The pathogenesis of IIM is largely ...
Genetic and functional analysis of the adaptive immune response
(2023-02-01)
The cells of the adaptive immune system rely on somatic recombination of V, D and J genes to obtain a vast range of specificities. T cells use four chains encoded by three genomic loci, to produce alpha/beta or gamma/delta ...
Cytochrome P450 pharmacogenetics : implications for anticancer and warfarin therapy
(2014-12-22)
There is a pronounced interindividual variability in the drug disposition, response and toxicity. Pharmacogenetics aims at identifying genetic biomarkers that could help to increase the drug efficacy, reduce
adverse drug ...
Genetic and serological characteristics of tissue-specific autoimmune disease
(2018-05-08)
The immune system has evolved to protect us from infectious disease and not to overreact to our own tissues or commensal flora. Immune system attack directed against self-tissue is referred to as autoimmune disease, a group ...
Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients
(2010-03-26)
Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and ...
Systemic stress response and hyperglycemia after abdominal surgery in rat and man
(2008-10-23)
Surgical trauma results in a complex neuroendocrine and metabolic response known as the systemic stress response, which is initiated by neuronal and humoral signals from the site of the injury. These signals converge at ...
Transcriptional regulation of healthy and diabetic pancreatic beta-cell gene expression
(2008-11-07)
Hyperglycemia, deficient insulin secretion, and insulin resistance are the characteristic pathogenetic features of type 2 diabetes (T2D), hallmarked by functional and survival defects of the insulin-producing islet beta-cell. ...
Studies on the effects of thyroid hormone on cholesterol and lipoprotein metabolism
(2012-11-22)
Elevated plasma lipids, particularly cholesterol within low density lipoproteins, is an important risk factor for developing atherosclerosis which can cause angina pectoris, myocardial infarction, and stroke. Thyroid hormone ...