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Functional studies of the ubiquitin-proteasome system using GFP-based reporters
(2002-11-21)
Ubiquitin-dependent proteasomal degradation is of paramount importance for cellular processes such as cell cycle progression, transcriptional regulation, apoptosis and disposal of misfolded and aberrant proteins. Moreover ...
Immune regulation and modulation of allergy and inflammatory diseases
(2012-08-23)
Inflammation is evoked in defence against invading pathogens entering the body. Sometimes inflammation is started against harmless antigens, which leads to allergic diseases, or against self-antigens or commensal microbiota ...
Genetic studies of follicular and mantle cell lymphoma
(2005-04-22)
Non-Hodgkin lymphoma is a malignancy derived from lymphoid tissues. In Sweden, non-Hodgkin lymphoma constituted 3% of all cancers recorded in 2003. Follicular and mantle cell lymphoma are the two types of non-Hodgkin ...
The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily ...
The role of transcriptional repression in Shh signalling and patterning of the ventral neural tube
(2004-05-07)
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vital role in determining cell fate and patterning during embryonic development. In vertebrates, Sonic Hedgehog (Shh) act ...
Chemokines and chemokine receptors during viral infections in man
(2007-11-08)
Chemokines and chemokine receptors are critical mediators of cell migration during immune surveillance, inflammation and development. The generation of antibody responses depends on B and T cell collaboration within germinal ...
On age related changes in axons and glia of the central nervous system
(2002-08-09)
A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the ...
Long-term exposure to air pollution from road traffic and development of airway and allergic diseases in children
(2012-11-22)
Allergic diseases are of great public health concern and constitute one of the most prevalent childhood illnesses. Air pollution exposure is related to several types of adverse health effects. There are, however, limited ...
Bringing order to disorder : structural and functional analysis for development of strategies to target MYC
(2014-09-05)
Several cellular processes such as cell cycle progression, apoptosis, cell adhesion and motility, cell growth, angiogenesis and differentiation are regulated by the MYC (here MYCN and c-MYC) proto-oncogenes. Elevated ...
Immune mechanisms behind plaque vulnerability : experimental and clinical studies
(2010-10-21)
Physical disruption of atherosclerotic plaques causes many acute
thrombotic complications such as myocardial infarction and stroke. The
resistance of the atherosclerotic plaque to disruption depends in part on
the ...