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Persistent geotropic nystagmus : a different kind of cupula pathology
(2014-02-04)
In patients with positional vertigo a persistent positional direction-changing nystagmus (PDCN) of apogeotropic direction (a-PDCN) in the supine yaw plane has been described earlier 1-5. It has been suggested that the ...
Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes
(2004-10-29)
The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and ...
Locomotor pattern generation in the spinal cord : studies in adult lamprey and zebrafish
(2011-03-07)
The overall objective of this thesis is to characterize the mechanisms involved in the generation of locomotor activity in the spinal cord. To this end, we initially used the lamprey spinal cord to determine the transmitter ...
Missed opportunities : prevention of mother-to-child transmission of HIV in Uganda
(2012-04-05)
Background: Despite the existence of effective interventions such as prophylactic antiretroviral medicines, mother-to-child transmission (MTCT) of HIV is still a major reason for HIV transmission in sub-Saharan Africa. ...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs ...
Aspects on the modulation of potassium channels in insulin-producing beta-cells
(2006-10-27)
This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits ...
Biomechanics of back extension torque production about the lumbar spine
(2002-02-01)
The aim of this thesis has been to develop a realistic mechanical description of lumbar back extension torque production. Such a description is desirable for understanding how back extension torque is generated as well as ...
Self-rated health : biobehavioral determinants with focus on inflammatory factors
(2010-05-28)
Self-rated (subjective) health is an independent predictor of future
mortality, but neither the mechanisms behind this relation nor the
biological determinants of poor self-rated health are known. Inflammatory
cytokines ...
Expression, recognition and usage of laminin-8 (a4b1g1, Lm-411) by monocytes and neutrophils
(2004-09-17)
Laminins (LNs) are a family of large alphabetagamma heterotrimeric glycoproteins found in all basement membranes (BMs). They are expressed in a tissue- and developmental stagespecific manner and implicated in vital cellular ...
Pursuing the fever trail : pathogenesis of blood-stage P. falciparum malaria and pregnancy
(2008-05-19)
The burden of the most virulent form of human malarias, Plasmodium
falciparum, is concentrated among young children and pregnant women in
sub-Saharan Africa. Excessive sequestration of parasite-infected red
blood cells ...