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Molecular and cellular strategies to enhance efficacy of T cell-based cancer therapy
(2006-09-06)
A combined approach of vaccination with β2-microglobulin (β2m)-deficient dendritic cells (DCs) and granulocyte-macrophage colony-stimulating factor (GM-CSF) as a potent adjuvant may link cellular and molecular strategies ...
Cancer vaccine strategies and studies of human thioredoxin reductase splice variants
(2010-05-28)
Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I ...
On neonatal asphyxia : clinical and animal studies including development of a simple, safe method for therapeutic hypothermia with global applicability
(2011-10-11)
Recent randomized clinical trials show that hypothermia can decrease brain dysfunction in newborn infants at risk for hypoxic-ischemic encephalopathy.
One goal of the present study was to develop an alternative to ...
AIDS and endemic Kaposi's sarcoma development : comparison by histopathology, virology (HHV8/KSHV) and cytogenetics
(2005-08-30)
Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like
lesion with spindle cells (SC) affecting the skin, lymphnodes and viscera
which is found in four different clinico-epidemiological forms as Classic
KS ...
Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs
(2014-05-19)
Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance ...
Interaction-mediating sequences within class I viral fusion glycoproteins : their roles in viral infection and in applications
(2015-10-23)
Class I viral fusion glycoproteins facilitate fusion of the viral envelope with cell membranes and entry of the virus into the cell, through extensive short sequence-specific interactions. Regions mediating these interactions ...
Identification and characterization of a proteasome deubiquitinase inhibitor
(2014-01-10)
The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells. The FDA approval of bortezomib for the treatment of ...