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Craniofacial bone reconstruction with bone morphogenetic protein-2
(2011-10-19)
Bone defects in the craniofacial area are a clinical challenge and can be the result of trauma, tumour resection or congenital malformations. The golden standard for reconstruction is autologous bone grafts, but bone may ...
Impact of candidate genes on obesity and type 2 diabetes
(2011-03-11)
Obesity and type 2 diabetes (T2D) have strong genetic components. Identification of susceptibility genes in both diseases will give better knowledge of their pathomechanisms and future therapies. In this thesis, the candidate ...
Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed ...
Estrogens and lymphoma growth
(2015-05-25)
Lymphomas are generally not considered as endocrine-associated cancers. Nevertheless, most lymphoid malignancies show a gender differencein incidence and prognosis, with males being more affected.The molecular mechanism ...
Lower urinary tract dysfunction in children with chronic kidney disease : before an after renal transplantation
(2014-11-14)
Chronic kidney disease (CKD) in children is a complex condition with the risk of progression to end-stage renal disease (ESRD) requiring dialysis or renal transplantation. Children with CKD and pediatric renal transplant ...
Molecular mechanisms underlying the oncogenic function of SS18 and SSX
(2008-01-04)
The SS18 and SSX genes were initially identified based on their
reoccurrence as fusion partners in synovial sarcoma. As a result of the
specific chromosomal translocation t(X:18), the SS18 gene from chromosome
18 becomes ...
Bereavement in adulthood and risks of incident and recurrent cardiovascular diseases
(2022-04-29)
Bereavement, the loss of a family member or a loved one, is a severely stressful life event that may occur at least once in most individuals’ life. Bereaved persons are likely to be influenced by the loss in multiple aspects ...
Local recurrence after breast conserving surgery in breast cancer
(2002-08-30)
The general aim of this thesis was to gain increased insight into the problem of local recurrences after breast conserving surgery for breast cancer. In a population-based cohort of 4,694 women with invasive breast cancer, ...
Intrauterine immunology in allergy and infection
(2009-01-02)
Pregnancy is interesting from an immunological point of view. The maternal immune system has to tolerate the fetus and at the same time also protect against infection. The placenta is not a completely tight barrier: in ...