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Costs and consequences in perioperative care : analytic models in studies on pain treatment and on haemodynamic optimization of elderly patients
(2011-01-20)
Background: Because resources are scarce in health care, costs and consequences of new interventions must be assessed to support informed policy decisions.
This thesis analyses the cost-effectiveness of advanced ...
Autoantibody recognition of collagen type II in arthritis
(2013-03-13)
Autoantibodies against collagen type II (CII), a protein localized in the joint cartilage, play a major role in collagen-induced arthritis (CIA), one of the most commonly used animal models for rheumatoid arthritis (RA). ...
A study on the E3 ligase TRIM21/Ro52
(2008-01-04)
Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 ...
Heart failure : studies of prognosis and advanced therapy
(2017-03-09)
Background: Heart failure (HF) is a major health problem affecting 2-3% of the Western population. The clinical syndrome of HF is associated with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Around 50% of the ...
Targeting of the Myc pathway as a novel approach for cancer therapy
(2006-11-24)
As transcription factors, Myc-family proteins function upstream of signaling pathways and regulate cell proliferation, differentiation, angiogenesis, apoptosis and transformation. Precisely regulated Myc expression is ...
Structural, interpersonal, and individual factors influencing sexual orientation-based disparities in mental health : a socio-ecological perspective on sexual minority stigma
(2020-08-28)
Background: Compared to heterosexual individuals, sexual minorities (e.g., those identifying as gay, lesbian, or bisexual) are at higher risk of several mental health problems, including suicidality, substance abuse, ...
NR4A orphan nuclear receptors in immediate early regulation of retinoid signaling and neuroprotection
(2010-05-14)
NR4A receptors show distinct properties that make them unique within the family of nuclear receptors. They lack a ligand-binding cavity and a canonical coactivator-binding site and they are induced both in vivo and in vitro ...