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Studies on neuronal signaling in the hippocampus related to development, pathogenesis and treatment of mood disorders
(2010-11-12)
The hippocampus is a central organ in the brain which is interconnected with different cortical regions and plays an important role in memory and learning processes. The anatomical position of the hippocampus together with ...
Pathogenesis of Alzheimer's disease : focus on amyloid β-peptide, homocysteine and metals
(2006-08-18)
Alzheimer's disease (AD) is a complex dementia disorder. It is characterized by the neuronal and synaptic loss, presence of neurofibrillary tangles and senile plaques, composed of amyloid β-peptide (Aβ) in the brain. ...
Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal
(2014-01-28)
Less than 50% of malignant mesothelioma patients respond to standard chemotherapy treatment and there is a great need to identify these patients, and find their best treatment options. The aim of this thesis was to increase ...