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Socioeconomic disadvantage in childhood and later risk of schizophrenia and other psychoses : national register-based studies
(2010-11-19)
Aim: The aim of this thesis was to analyse the association between various types of indicators of socioeconomic disadvantage in childhood and the risk of later developing schizophrenia and other psychoses. Furthermore, the ...
Genetic and functional analyses of diabetic nephropathy with focus on chromosome 3q
(2010-05-14)
Diabetic nephropathy (DN) is a complex disease affected by both genetic and environmental factors. Genetic and functional analyses of the susceptibility and/or resistance genes in DN may provide useful information for ...
Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans
(2006-04-28)
ABH and Lewis antigens are carbohydrate epitopes (glycans) found on a wide variety of cell surfaces. They are involved in many biological processes, e.g transplantation rejection, bacterial and viral adhesion, cell-cell ...
Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy
(2017-04-28)
The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, ...
Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system
(2019-05-03)
The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, ...