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Toxicological aspects of bile acids and human fecal water on cultured human colon carcinoma cells
(2001-05-11)
Colorectal tumorigenesis involves activation of mutations in
proto-oncogenes, such as ras and c-myc, as well as mutations that
inactivate tumor suppressor genes including the APC and the p53 gene.
These genetic events, ...
Studies on cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in lymphomas
(2008-08-22)
Classical Hodgkin lymphoma (cHL) is a malignant disorder with striking
inflammatory features. Since cysteinyl leukotrienes (cysLTs) are potent
inflammatory mediators it was of interest to study their potential role
in ...
Digital intraoral radiography : determination of technical properties and application evaluations
(2002-05-03)
Digital registration of intraoral radiographs was introduced about 1990. One of the first systems on the market was the Sens-A-Ray (Regain Medical Systems AB, Sundsvall, Sweden). At the time of the introduction, it was ...
Cytochrome P450 pharmacogenetics : implications for anticancer and warfarin therapy
(2014-12-22)
There is a pronounced interindividual variability in the drug disposition, response and toxicity. Pharmacogenetics aims at identifying genetic biomarkers that could help to increase the drug efficacy, reduce
adverse drug ...
Activation of the novel PDGFS by plasminogen activators in tumorigenesis
(2010-04-30)
Members of the platelet-derived growth factor (PDGF) family are mitogens for cells of a mesenchymal origin and have important functions both during development and in the adult. Their role in developmental processes has ...
Visuo-thermal congruency modulates the sense of body ownership
(Springer Nature, 2022-09-08)
Thermosensation has been redefined as an interoceptive modality that provides information about the homeostatic state of the body. However, the contribution of thermosensory signals to the sense of body ownership remains ...
Development of surgical techniques in craniofacial reconstruction
(2016-11-02)
Introduction: Facial fractures are common and either the injury or the surgical treatment may cause sequelae including diplopia, visual loss, dystopia, enophthalmos, scarring, soft tissue affection and sensory disturbances. ...
Biological activities of novel platelet-derived growth factors, PDGF-C and PDGF-D
(2004-09-17)
Platelet-derived growth factors (PDGFs) belong to the PDGF/VEGF (vascular endothelial growth factor) family of growth factors. Members of this family share a common structural feature, a conserved PDGF/VEGF homology domain, ...
Integrin-interacting proteins in human cancer progression
(2010-04-02)
Integrins are the major transmembrane receptors for the extracellular matrix (ECM) which regulate a diverse array of cellular functions crucial to tumor cell migration, invasion, proliferation and survival. Integrins contact ...
Repressing the hedgehog signalling pathway
(2007-11-28)
The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation of the pathway is found in tumours. Mutations in Hh pathway components are found in several tumour types, including basal ...