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Genome-wide patterns of histone modifications in fission yeast
(2010-01-22)
DNA is wrapped almost two times around a group of proteins called histones to form a chromosomal structure known as the nucleosome. Both DNA and histones can be modified with different chemical tags by several enzymes to ...
Epidemiological studies in Malaysia and Sweden on associations between smoking, silica exposure and the risk of developing rheumatoid arthritis
(2012-11-12)
Rheumatoid arthritis (RA) is a chronic, inflammatory disease, frequently associated with joint destruction. Knowledge regarding the aetiology of RA is mainly generated on Caucasian populations. Less is known about RA in ...
Pain, mechanisms of fatigue and autonomic function in rheumatoid arthritis
(2016-11-14)
Rheumatoid arthritis (RA) is a disabling chronic autoimmune disease characterized by joint pain, and potentially leading to a serious decay of life quality. Pain remains the most important problem for patients with RA, and ...
Studies on novel immunosuppressive agents in experimental arthritis
(2006-11-24)
Rheumatoid Arthritis (RA) is a chronic inflammatory disease of the joints. The hallmark of RA is persisting inflammation in diarthrodial joints with infiltration of leukocytes, thickening of the synovial lining layer and ...
Studies of the synovial membrane in chronic rheumatic joint disease
(2006-04-26)
Background: The synovial membrane (SM) outlines the inner cavity of synovial joints except for cartilage surfaces. The SM is the target organ of immune-mediated responses in chronic arthritis, including rheumatoid arthritis ...
Rheumatoid arthritis : pharmacological modulation of cytokines : aspects of clinical response and endocrine regulation
(2006-01-06)
Rheumatoid arthritis (RA) is a systemic inflammatory disease primarily affecting the joints. In the pathogenesis several cells of the immune systeme and messengers of the immune systeme, cytokines, are important. In this ...
The risk of malignancy in women with endometriosis
(2010-03-05)
The aim of this thesis was to investigate the association between endometriosis and malignancies also after controlling for parity, to investigate the impact of endometriosis on survival after a malignancy diagnosis and ...
Platelet-regulated CD4+ T effector cell responses in atherosclerosis
(2021-09-30)
Atherosclerosis (AS) is a thrombotic and inflammatory disease of the medium- and largesized arteries. Platelets participate in all stages of its formation, forming thrombus at the ruptured plaque; meanwhile, CD4+ T cells ...
Nerve injury induced pain and spinal cord stimulation
(2010-11-02)
Chronic neuropathic pain caused by injury to or disease in the nervous system is relatively common and results in major suffering, poor quality of life and incapacity. Such pain is a therapeutic challenge because a ...
Neuropsychological functions in women with borderline personality disorder and a history of suicide attempts
(2009-09-11)
Borderline personality disorder (BPD) is a complex psychiatric disorder that leads to intense suffering for afflicted individuals, and extensive use of health care resources. Self-injurious and suicidal behaviors are common ...