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Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease
(2007-08-06)
BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority ...
Development and biomedical applications of highly sensitive enzyme activity assays of thioredoxin, thioredoxin reductase and glutaredoxin
(2013-05-23)
Oxidative stress is implicated in the pathogenesis of many human diseases, thus it is interesting to study the relationship between antioxidants, the development and progression of diseases. The thioredoxin and glutaredoxin ...
Bacterial thioredoxin systems as potential drug targets in novel antimicrobial therapies
(2013-02-08)
Antimicrobial resistance is a big problem in modern medicine. One of the key components in the combat is the characterization of novel drug targets and the development of new classes of compounds targeting them. In the ...
Family history, genes and gene-environment interaction in risk and prognosis of non-Hodgkin lymphoma
(2017-01-04)
Non-Hodgkin lymphoma (NHL) is a heterogeneous group of malignant diseases arising from lymphocytes. There are about 40 subtypes according to the World Health Organizations classification system, differing in morphology, ...
Intracellular pathways involved in formation and degradation of prions
(2009-10-23)
Prions cause invariably fatal neurodegenerative diseases, in which a misfolded host-encoded protein appears to be the main, if not the only, component of the infectious agent. During disease, a normal cellular protein, ...