Search
Now showing items 1-10 of 15
Triggering and mechanisms of natural killer cell mediated cytotoxicity
(2008-08-01)
Natural killer (NK) cells are innate immune cells that contribute to defense against infected and transformed cells by target cell killing and cytokine release. In addition, data suggest that NK cells contribute to immune ...
The effect of Gal alpha(1,3)gal glycopeptide-conjugates and human serum on HIV-1 infection and replication
(2012-10-23)
The first step in the entry of HIV-1 is the binding of the viral envelope glycoprotein (gp120) to the CD4 molecule expressed mainly on T helper cells. Upon binding, gp120 undergoes a series of conformational changes that ...
HMBG1 and other soluble factors in HIV-1 pathogenesis
(2009-01-30)
The innate immune system is the first defense mechanism invading
pathogens encounter. Macrophages, dendritic cells and
cytokines/chemokines are important factors for the functionality of the
innate immunity, and provide ...
HIV-2 genetic evolution and viral dynamics
(2006-05-03)
HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. However, why this lower viral load is seen is not known. In ...
Altering HIV-1 envelope glycoprotein maturation and its effects on viral infectivity
(2011-11-11)
HIV-1 is dependent on its envelope glycoprotein (Env) to initiate infection. Env binds to cellular receptors and mediate the following fusion of the viral envelope with the cell plasma membrane. In an attempt to inhibit ...
Identification of genes that regulate arthritis and IgE production in rat and human
(2005-08-08)
Multiple genome-wide scans have identified quantitative trait loci (QTLs) that influence inflammatory diseases on chromosome 4q42 in DA rats. Several of the QTLs overlap with the QTL designated Oia2 (Oil-induced arthritis-2), ...
Retinoids in the modulation of vascular inflammation
(2004-12-24)
Vascular disease is multifactorial. Smooth muscle cells, the major constituent of the normal vessel wall, play a pivotal role. The pathogenesis includes cellular differentiation, proliferation and inflammatory activation. ...
Emergency contraception among young people in Uganda : user and provider perspectives
(2007-11-21)
Background: The maternal mortality ratio for Uganda is 435/100,000 live
births. Between 12-30 percent of the maternal deaths are due to induced
abortions. According to the 2007 Uganda demographic and health survey
(UDHS), ...
Antimicrobial and xenobiotic defence in the mammalian testis
(2012-05-24)
Different mechanisms exist in the mammalian testis to protect the germ cells from autoimmune attack, invading microbes, and xenobiotic induced toxicity, which would otherwise be deleterious to the preservation of fertility. ...
Approaches to modulate vaccine-induced antibody responses
(2017-09-15)
Most successful licensed vaccines mediate protection by inducing antibody responses capable of protecting the individual from infection or disease. Despite the availability of many effective vaccines, we lack knowledge ...