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The role of estrogen regulation in brain development and neurodegeneration
(2009-11-27)
Estrogen is a steroid hormone which regulates neuronal control of reproduction. It has other important roles in the central nervous system (CNS), including trophic effects on dendritic spine morphology that provide structural ...
The role of ABC transporters and inflammation in drug-resistant epilepsy
(2017-11-16)
This thesis explores two pathologies thought to be related to drug resistance in epilepsy that may themselves be causally related: 1) overexpression of drug transporters in capillaries and 2) inflammation. With regard to ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...