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Alcohol consumption during pregnancy : how do we separate myth from reality?
(2004-11-26)
The overall aim of this thesis, consisting of five studies, was to examine what midwives do when they encounter women with alcohol use during pregnancy; to evaluate and implement screening instruments aimed at identifying ...
Anti-citrulline immunity in rheumatoid arthritis : characterization of peptide-HLA interactions and CD4+ T cell responses
(2018-10-25)
Rheumatoid Arthritis (RA) is a complex, systemic autoimmune disorder characterized by chronic inflammation in small joints in hands and feet. It is a common disease that if untreated leads to joint destruction, disability, ...
p53 guardian of the genome and target for improved treatment of leukemia
(2007-03-02)
P53 acts in several cellular processes as cell cycle checkpoints, DNA
repair senescence and the surveillance of genomic integrity. Wt p53
inhibits cancer processes by causing cell cycle arrest and apoptosis. P53
is ...
Role of integrin signaling in cell proliferation and survival
(2005-05-27)
Integrins function as transmembrane cell adhesion receptors for the surrounding extracellular matrix (ECM). Within the tissues, integrins attach the cells to the surrounding ECM and sense the ECM environment by triggering ...
Angiostatic mechanisms of endogenous angiogenesis inhibitors
(2003-05-02)
Angiogenesis, the process of sprouting of new capillaries from the existing blood vessels, is essential for tumor growth and metastasis. Angiostatin was discovered as the first specific endogenous angiogenesis inhibitor ...
DNA damage-induced cell death : the role of caspase-2
(2009-01-02)
Activation of a family of cysteine proteases, called caspases, is an
important event during apoptosis. In comparison to other caspases, less
is known about regulatory functions of caspase-2. Previous studies from
our ...
Apoptotic signaling in lung carcinoma cells : with focus on mechanisms of radioresistance
(2003-05-02)
In this thesis, IR-induced apoptotic signaling was studied in a panel of lung carcinoma cell lines. The goal was not only to achieve a better understanding of the process, but also to identify possible targets for ...