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Causal inference in epidemiological research
(2009-01-16)
Traditionally, statistics has been viewed as the branch of science which
deals with association. Many epidemiological research questions, however,
are concerned with causation, not association. In this thesis we ...
Fatal attraction : the relationship between patients and their eating disorders, an interpersonal and attachment perspective
(2017-10-27)
Eating disorders are severe psychiatric illnesses, causing immense suffering for patients, but also for their families and friends. Ambivalence about change and treatment resistance are common, and relapse rates are high. ...
Mammalian sperm flagella and cilia
(2009-04-17)
In mammals, both sperm flagella and cilia are axoneme-containing organelles. The sperm flagella are major parts of the spermatozoa that are male gametes produced in the testis from progenitor spermatogonia through a process ...
Novel aspects of metabolic regulation and inflammation in human adipocytes
(2015-04-28)
The significance of adipose tissue and obesity has been recognized in numerous pathologies. However, the mechanisms behind this connection are not yet completely understood. The aim of this thesis was to investigate the ...
Genetic studies of candidate genes in eczema
(2008-01-11)
Eczema is a common inflammatory skin disorder characterised by itching and relapsing eczematous lesions. It usually presents in early childhood and affects about 10-20% of all children. The background is multifactorial, ...
Angiogenesis modulates obesity and insulin sensitivity
(2014-12-17)
Both white and brown fat are highly vascularized tissues and vascular functions in adipose tissues remain largely unknown. In this thesis work, we aimed to study blood vessels in modulation of adipose tissue functions under ...
Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling
(2015-09-22)
Cancer is, despite rapid progress in development of new targeted therapies, still mainly
treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned
conventional therapies often meet general ...
Crosstalk of human mesenchymal stromal cells with the cellular components of the immune system
(2013-08-20)
Using the potential of immune regulatory cell populations for cellular therapy constitutes an attractive tool to obliterate imbalances of immune responses in inflammatory disorders. In this context, adoptive transfer of ...