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Sarcopenia
(2005-11-21)
Sarcopenia (Greek; sarcos: flesh, and penia: poverty) is the pronounced muscle loss that affects the aging population. Sareopenia of the leg muscles results in loss of independence and increased morbidity in the elderly. ...
Single cell analysis of checkpoints in G1
(2005-09-15)
It is becoming evident that defective cell cycle regulation is an important property of the cancer cell. The restriction point (R), a G1 checkpoint after which cell cycle progression becomes independent of extracellular ...
Quantitative echocardiographic methods for patients with acute coronary syndrome
(2014-07-09)
Background: The aim of this thesis was to evaluate two diagnostic and two prognostic quantitative echocardiographic methods for patients with acute coronary syndrome (ACS).
Methods:
Velocity tracking (VeT) presents ...
Systemic stress response and hyperglycemia after abdominal surgery in rat and man
(2008-10-23)
Surgical trauma results in a complex neuroendocrine and metabolic response known as the systemic stress response, which is initiated by neuronal and humoral signals from the site of the injury. These signals converge at ...
Intrauterine immunology in allergy and infection
(2009-01-02)
Pregnancy is interesting from an immunological point of view. The maternal immune system has to tolerate the fetus and at the same time also protect against infection. The placenta is not a completely tight barrier: in ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Musculoskeletal injuries and generalized joint laxity in ballet dancers
(2012-09-13)
Aims: To examine the incidence and type of musculoskeletal injuries in classical ballet dancers, to analyse these injuries in relation to absence from performance, and to identify dancers at risk of frequent injuries in a ...
Diet, lifestyle and chronic kidney disease
(2018-09-18)
Chronic kidney disease (CKD) is a rapidly growing public health problem, affecting 5-10% of the general population, and individuals with CKD have a substantially increased risk of morbi-mortality. Early detection and ...
Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice
(2016-08-10)
Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and ...
Bringing order to disorder : structural and functional analysis for development of strategies to target MYC
(2014-09-05)
Several cellular processes such as cell cycle progression, apoptosis, cell adhesion and motility, cell growth, angiogenesis and differentiation are regulated by the MYC (here MYCN and c-MYC) proto-oncogenes. Elevated ...