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Register-based studies of delivery outcome after maternal use of some common drugs
(2008-11-07)
This thesis aimed to study neonatal outcome including the presence of
congenital malformations and to describe maternal characteristics for
women using some common drugs during pregnancy. Drugs used in one benign
condition ...
Genetic studies of follicular and mantle cell lymphoma
(2005-04-22)
Non-Hodgkin lymphoma is a malignancy derived from lymphoid tissues. In Sweden, non-Hodgkin lymphoma constituted 3% of all cancers recorded in 2003. Follicular and mantle cell lymphoma are the two types of non-Hodgkin ...
Familial hypercholesterolemia in Sweden : genetic and clinical studies
(2021-11-12)
Prevention of premature disease and death from cardiovascular complications of atherosclerosis is an important goal for public health, and the early identification of individuals with increased risk is an important goal ...
Targeting polo-like kinase 1 in pediatric leukemia
(2020-03-24)
Acute lymphoblastic leukemia (ALL) is one of the most common cancers among children in the world, with almost 90% complete remission rate after the primary treatment. However, some patients are resistant to treatment and ...
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(2020-10-07)
In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also ...
Imaging of the brain opioid system in amphetamine dependence
(2017-10-31)
Amphetamine dependence is a global health problem, often giving rise to severe medical and social complications in affected individuals. Unfortunately, there is still limited evidence for any specific treatment that would ...
Hitting the right targets : a study of molecular mediators of sensitivity to novel potential targeted therapies in cutaneous malignant melanoma
(2020-04-24)
Cutaneous malignant melanoma (CMM) is the deadliest form of skin cancer with a 5-year overall survival (OS) rate of less than 10% among patients diagnosed with disseminated disease. During the past decade the emergence and ...