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Exhaled nitrogen oxides and carbon monoxide in asthma and cystic fibrosis : markers of inflammation?
(2008-11-21)
Background: Exhaled markers of airway inflammation have attracted much
interest as potential tools for monitoring the bronchial inflammation of
respiratory disease. Exhaled nitric oxide (NO), its metabolites nitrite
and ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
Gliomas are the most common glial neoplasms, accounting for nearly 70% of
all primary brain tumours. The progression of low-grade gliomas into more
aggressive tumours is supported by the abnormal function of several
prot ...
Biochemical and structural studies of pre-mRNA splicing
(2001-08-31)
When eucaryotic genes are expressed, they are transcribed into pre-mRNAs (precursor mRNAs) that need extensive processing before they can be exported from the nucleus as mRNAs and translated into proteins in the cytoplasm. ...
The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation
(2006-09-15)
This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response ...
On vascular endothelial growth factor B and platelet-derived growth factor C : two members of the VEGF/PDGF family of growth factors
(2001-03-30)
Vascular endothelial growth factors (VEGFs), platelet-derived growth factors (PDGFs) and their receptors are important for normal development. They have also been implicated in many pathological conditions. VEGFs have been ...
Exploring the impact of virtual patient design : medical students' small group learning around medical error
(2020-02-27)
Background: The demands on medical and healthcare practitioners are continuously changing, with new technologies, treatments and regulatory guidelines emerging each year. One such example is increased focus on the impact ...
From gene mutation to gene expression : studies on multiple endocrine neoplasia type 1 and vascular endothelial growth factors
(2006-10-27)
Multiple Endocrine Neoplasia type 1, MEN1, is an inherited cancer syndrome whose gene was localised to chromosome 11q13 in 1988. A number of !candidate genes were characterised before the MEN1 gene was cloned in 1997. DNA ...