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DNA microarray approaches to understanding the regulation and evolution of gene expression networks
(2009-09-24)
DNA microarray technology allows biological and medical research to shift from investigation of individual functions of a few related genes to the whole genome level. This creates opportunities for discovery of complex and ...
Characterization of F-box proteins and their target substrates in cancer
(2014-11-11)
Protein degradation, by means of ubiquitylation tagging for subsequent degradation by the ubiquitin-proteasome system (UPS), has opened up a newfound way of protein degradation some three to four decades back. Termed the ...
Modulation of the deubiquitinating system in viral infection, lymphoid cell activation and malignant transformation
(2007-11-16)
Most cellular proteins are affected by the conjugation of Ubiquitin (Ub),
which may regulate their stability, activity or localization. The family
of deubiquitinating enzymes (DUBs) removes Ub from conjugates and
regulates ...
Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models
(2007-09-07)
Osteoclasts are multinucleated bone-resorbing cells that have been
implicated in a variety of skeletal diseases e.g. osteoporosis,
rheumatoid arthritis and skeletal metastasis. Under physiological
conditions, the osteoclast ...
Influence of oxidative stress on aryl hydrocarbon receptor signaling
(2013-05-13)
The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per-Arnt-Sim) super-family of transcription factors. The ...
Long-term survival and survivorship in non-Hodgkin lymphoma patients in Sweden
(2020-12-11)
Non-Hodgkin lymphoma (NHL) is one of the top ten most common cancer types in Sweden. Although sometimes referred to as one disease, NHL is truly an umbrella term representing a heterogeneous group of diseases with varying ...
Platelet angiogenic activities and their regulation on endothelial progenitor cell functions
(2015-08-12)
Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which ...
Determination and use of radiobiological response parameters in radiation therapy optimization
(2001-11-23)
Optimization of radiation therapy is critically dependent on the use of patient related information. For this reason, radiobiological models describing the dependence of tumour and normal tissue responses on the irradiated ...
SNP technology and Alzheimer’s disease
(2003-02-21)
One major goal of genetic research is to understand the role of genetic variation. By far the most common type of such variation in humans involves single DNA bases, and is termed single nucleotide polymorphism (SNP). With ...
Molecular aspects of retinol uptake and activation
(2005-11-11)
Retinoids (vitamin A derivatives) are essential for a wide variety of physiological processes, including embryonic development, growth, vision, reproduction, and maintenance of various epithelia and the immune system. ...