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Molecular mechanisms controlling dynamin recruitment to sites of endocytosis by SH3-domain containing proteins
(2010-05-26)
Endocytosis is a general cellular mechanism, which regulates a number of important events, including recycling of synaptic vesicles. Clathrin-mediated endocytosis is the best-characterized endocytic pathway in the cell. ...
Stem cell differentiation, plasticity and regenerative mechanisms in the cholinergic system : implications for Alzheimer’s disease
(2008-02-25)
Stem cells are immature cells with self-renewal capacity. They are able
to differentiate into multiple lineages that may serve as a source of
expandable cells for various applications. To generate cell populations
of a ...
HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation
(2008-12-26)
Currently, big efforts in HIV-1 research are devoted to the design of a
HIV-1 vaccine. However, no successful vaccine is yet available, also due
to the lack of basic knowledge in HIV-1 pathogenesis which is still
profound. ...
Role of water channels in kidney and lung
(2009-11-27)
Aquaporins (AQPs) are membrane proteins that function as water channels facilitating a rapid and regulated transport of water across cell membranes. AQPs in kidney and lung play pivotal roles for the regulation of water ...
Functional aspects of prothrombin in bone
(2010-05-14)
Prothrombin (PT) is the inactive zymogen to the serine protease alpha-thrombin which in the coagulation cascade is responsible for clot formation through converting fibrinogen to fibrin. PT has been shown to be present in ...
The regulation of B cell responses in systemic autoimmunity
(2017-04-10)
Our immune system is a complex network made up of physical barriers and specialized proteins, cells and organs that all work together to prevent pathogens from causing disease in the body. Once the immune system has ...
Malocclusion among adolescents : qualitative and quantitative studies of the impact on oral health and daily life
(2016-11-17)
Though not considered pathological conditions, malocclusions and their impact have traditionally been assessed from a professional point of view. This could be due to their multifactorial aetiology and the great variation ...
Oral health and olfactory function : what can they tell us about cognitive ageing?
(2020-04-17)
The objective of this thesis was to advance our understanding of whether oral health and olfactory function may predict accelerated cognitive ageing. Data from two Swedish study populations and one from the United States ...
Colonoscopic surveillance in familial colorectal cancer
(2014-10-03)
Colorectal cancer (CRC) is a disease with a high and rising incidence in the industrialized countries. It is the third leading cause of death among cancers in Sweden and the forth worldwide. Important etiological factors ...