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Investigation of genetic factors in multiple sclerosis
(2009-05-08)
Multiple sclerosis (MS) is a chronic disease where the transmission of signals in the central nervous system is affected leading to a broad range of symptoms. The aetiology of the disease is unknown but multiple genetic ...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly ...
Enzymatic activation of oxygen in the biosynthesis of polyketide antibiotics
(2009-09-04)
The electron structure of molecular oxygen (O2) is such that it cannot spontaneously react with organic molecules, a feature that protects organisms from oxidative stress. However, oxygenases can insert O2 in organic ...