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Galanin receptor subtypes in rodent models of mood disorders
(2010-03-05)
Major depressive disorder (MDD) is a serious mental illness, with a complex etiology. It is a multifactorial disorder caused by a combination of genetic, environmental and epigenetic factors. Exposure to stressful life ...
Colorectal cancer treatment and early response evaluation : how do we best evaluate treatment response?
(2010-02-05)
Colorectal cancer (CRC) is common, being responsible for around 12% of
new cancers in Sweden, and contributing heavily to the large numbers of
cancer deaths yearly. CRC is the second most common cause of cancer death
not ...
The galanin type 2 receptor: molecular biological, histochemical and electrophysiological studies
(2011-04-06)
In the present thesis, the aim was to probe the distribution and functions of galanin type 2 receptor (GalR2) in the rodent brain. In order to overcome the lack of a reliable antibody to localize GalR2 by immunohistochemistry, ...
Assessment of cognitive function in elderly patients with hip fractures
(2007-03-09)
Impaired cognitive function is common among elderly patients. The aim of this thesis was to illuminate the documentation of cognitive function in elderly patients with hip fractures and to study the effect of cognitive ...
Acanthamoeba castellanii as a host and model to study bacterial virulence
(2009-05-21)
Vibrio cholerae is the causative agent of cholera, a waterborne diarrheal disease and it is believed to be strictly extracellular bacterium. Cholera remains as a global public health threat affecting most of the developing ...
Repressing the hedgehog signalling pathway
(2007-11-28)
The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation of the pathway is found in tumours. Mutations in Hh pathway components are found in several tumour types, including basal ...
Studies of cohesin functions in the yeast and human DNA damage response
(2013-10-04)
Maintaining genome stability is critical to cell survival and normal cell growth and most human cancers display some form of genome instability. Genome instability is caused by multiple reasons and the ability to properly ...
Immunometabolic reprogramming during suppressive HIV-1 infection
(2022-05-10)
Since the implementation of antiretroviral therapy (ART), infection with human immunodeficiency virus type-1 (HIV-1) has been transformed into a chronic lifelong condition. The main obstacle for a HIV-1 cure is the persistence ...
Neuropeptides in the human postmortem brain : focus on galanin and its receptors in depression
(2016-11-25)
Neuropeptides represent the most diverse family of messenger molecules in the nervous system, which are co-expressed with key neurotransmitters in several brain regions. They modulate synaptic neurotransmission and have, ...
On functions of neurotrophic factors in taste buds and teeth
(2017-11-24)
Background: Chemosensory disorders affect approximately 15% of the U.S. population and an estimated 200,000 individuals visit a doctor each year for problems with their ability to taste or smell (NIDCD). Among the common ...