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Comparative sequencing of candidate genes in complex disease
(2006-02-17)
Complex multi-factorial diseases such as cardiovascular, metabolic, neurological and respiratory disorders affect a great number of people across the world. In the post-Human Genome Sequencing era, genome wide association ...
Redox regulation of T cells in autoimmunity
(2021-09-03)
Autoimmune disorders affect a significant part of the population and therefore present a serious health and economic burden. One of the most common autoimmune diseases is rheumatoid arthritis (RA), affecting 0.5-1% of the ...
Mechanisms of pain in autoimmunity : the role of antibodies
(2016-10-18)
Chronic pain in autoimmune diseases, like rheumatoid arthritis (RA), is a common and life- changing problem for many patients. Treatment is usually aimed at reducing inflammation and preserving the function of affected ...
Antibodies as pathogenic factors and biomarkers in rheumatoid arthritis
(2021-05-21)
Ever since the evolution of an adaptive immune system capable of creating immune receptors that may recognize self-antigens, we have been at risk of autoimmunity. There are over 100 different types of autoimmune diseases ...
Agnostic studies in epidemiology
(2023-02-24)
In epidemiology there has been an consistent effort to construct refined methods aiming towards the ability to draw casual inference between an exposure and an outcome. This thesis, partly inspired by the genome-wide ...
Antibody-associated inflammation in and outside the joint in rheumatoid arthritis
(2017-08-17)
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by pain, chronic inflammation and joint destruction. Epidemiological investigations in large populationbased cohorts have identified both genetic ...