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Chemokines and their role in dopaminergic development
(2009-11-06)
The main pathological hallmark in Parkinson s disease (PD) is the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN), affecting movements such as walking, talking and writing. Today, there is no ...
Microbial regulation of PPARgamma : nuclear receptor networks important for colonic homeostasis
(2008-05-23)
One of the central issues surrounding the physiology of good health is to
uncover and understand the molecular networks responsible for its
maintenance. The alimentary tract in particular, demands a properly
sustained ...
Pivotal role of the nuclear receptor PPARgamma in colon epithelial cells
(2004-02-27)
When symbiosis between the residential intestinal flora and the
epithelial cells of the gastrointestinal tract is broken one endpoint may
be chronic inflammation, e.g. Inflammatory Bowel Disease (IBD). The
disruption ...
The microbiome, PPARγ and AhR in the inflammation-metabolism interface within the gastrointestinal tract
(2014-04-04)
The mammalian body is a mosaic of different organisms - a holobiont, which contains all the biomolecules and their metabolites encoded in our eukaryotic genome and supplemented by an even larger pool of prokaryotic genes ...