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CYP2C19 and CYP2C9 : new aspects of pharmacogenetics and transcriptional regulation
(2010-09-24)
CYP2C9 and CYP2C19 mRNA expression in human hepatocytes, as measured
by real time PCR. Electrophoretic mobility shift assays revealed
sequence-specific binding of GATA-4, GATA-6, and ERα to the two adjacent
GATA binding sites and to the predicted ER...
Molecular epidemiology of tuberculosis
(2011-11-09)
Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy ...
Molecular characterization of Mycobacterium tuberculosis isolates in Mozambique
(2011-05-27)
diversity of spoligotypes with predominance of the Latin-American Mediterranean (LAM, n=165 or 37%); East African-Indian (EAI, n=132 or 29.7%); an evolutionary recent but yet ill-defined T clade, (n=52 or 11.6%) and the globally-emerging Beijing clone, (n=31...
Spread and distribution of drug resistance and compensatory mutations in Plasmodium falciparum
(2012-05-08)
In 2010 there were an estimated 216 million cases of malaria worldwide. In Honduras there were ~9000 cases of which 88% were due to Plasmodium vivax mono-infection. Chloroquine (CQ) resistant Plasmodium falciparum have ...
Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms
(2012-11-22)
Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of ...
Optimization of intravenous contrast media at computed tomography
(2012-05-09)
The administration of intravenous contrast media (IV CM) is essential for detecting lesions at most computed tomography (CT) examinations. The overall aim of this thesis is to investigate different aspects of IV CM ...
Primary reconstruction with implants in breast cancer : aspects of oncological safety and aesthetic outcome
(2011-04-28)
were operated with a new crescent-shaped expander implant and the result was compared with those seen after surgery with traditional expander implants (Paper II). Twelve patients were included, 6 preoperatively and 6 postoperatively, in a methodological...
Costs and consequences in perioperative care : analytic models in studies on pain treatment and on haemodynamic optimization of elderly patients
(2011-01-20)
Background: Because resources are scarce in health care, costs and consequences of new interventions must be assessed to support informed policy decisions.
This thesis analyses the cost-effectiveness of advanced ...
Social determinants of health care use for Ugandan children : does social capital matter?
(2011-05-16)
likelihood of using a public health facility. In direct contrast, children living in villages with high levels of perceived reciprocity (OR 0.69, 0.49 to 0.97) had a lower likelihood of using a public health facility than those who lived in villages...
Familial adenomatous polyposis : a patient perspective on life after surgery
(2011-05-20)
, the life-long nature of their illness and abdominal symptoms. Individuals use different strategies to minimize the effects of their illness on everyday life. The results from the self-reported questionnaires revealed that 91% of the individuals perceived...