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F‐box proteins as regulators of oncogenic pathways by ubiquitylation
(2011-09-21)
suppressor protein FBXW7/hCDC4 has been linked to human tumorigenesis through the targeted degradation of several important oncoproteins, including cyclin E. The ubiquitin-dependent turnover of cyclin E1 is regulated by phosphorylation and isomerization...
Mifepristone for preoperative treatment of uterine leiomyoma
(2011-04-29)
.014). The controls (N=15) had a percentual n.s. increase in volume of mean (± 95% Confidence interval), +8% (-10%, +26%) over time. The mifepristone group (N=12) had a significant volume regression of -27% (-47%, -8%), p=0.028 within the mifepristone group...
CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects
(2010-12-23)
% of Korean alleles. The frequency of the CYP2C19*17 allele was very low in Koreans (0.3%) compared to Swedes (20%) and this allele caused an increased enzyme activity in the Swedish subjects. Among subjects homozygous for CYP2C19*1, Koreans displayed...
Mathematical modelling of clinical applications in fluid therapy
(2010-09-10)
Background: This thesis presents a new application of fluid kinetic
analysis using mathematical tools to evaluate fluid therapy problems.
Several models were developed to mathematically handle fluid distribution
concerning ...
The clinical use of genetic analyses in colorectal cancer
(2011-11-22)
this screening, 6 candidate prognostic microRNAs were validated using TaqMan quantitative PCR in all 50 patients. We found that high expression of miR-185 and low expression of miR-133b correlated to poor survival (p=0.001 and p=0.028, respectively...
HLA genetics in multiple sclerosis
(2012-04-20)
*06:02 (below referred to as DRB1*15) which increases the risk of MS 3-fold compared with the general Swedish population where the lifetime risk of MS is 0.2%. Our group pioneered the identification of a protective effect of the HLA class I region...
A treatment-strategy-based classification system for decision-making in patients with low-back pain : a biomedical approach: development and inter-examiner reliability
(2012-04-12)
Background: Low-back pain (LBP) is a common, disabling and costly disorder and its treatment includes a range of interventions. Increased demands are put on effective care and rehabilitation offered to this population. ...
Epidemiology, risk and protective factors of self-immolation : a study from Iran
(2013-04-04)
Background: Suicide by self-burning (self-immolation) is one of the suicide methods that is far more common in low-middle income countries than in high-income ones. Iran is one of the countries that has a high rate of ...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...
Autoimmune diabetes in adults : epidemiological studies of risk factors and mortality
(2012-09-07)
and occupation), sleep disturbances and psychological well-being on the risk of developing autoimmune diabetes in adults, to investigate whether genetic variation in the melatonin receptor 1B (MTNR1B) contributes to the association between poor sleep and type 2...