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Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
Development of novel DNA vaccine and immunotherapeutic approaches
(2009-08-06)
. Our data provide evidence in support of the theory that Btk negatively regulates both TLR9 activation and expression in mouse splenic B cells. Thus, down regulation of Btk with plasmid expressing short hairpin RNA (shRNA) and attaching TLR9 ligands...
Brain imaging in preterm infants at term equivalent age : value and comparison of MRI and ultrasound
(2009-05-15)
Cranial ultrasound (cUS) and magnetic resonance imaging (MRI) are the two most commonly used brain imaging techniques in preterm infants. cUS can be performed at the bedside and detects all major brain abnormalities ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
Storage and transfusion of platelets : in vitro and in vivo studies in healthy volunteers and in allogeneic hemapoetic progenitor cell transplant recipents
(2009-03-13)
Early studies in the 1960´s showed that platelet (PLT) transfusions
significantly reduced the incidence of fatal hemorrhages. Together with
the advances in the hematology and transplantation field, easily
accessible ...
Methods, tools, and computational environment for network-based analysis of biological data
(2023-02-27)
Cancer currently affects more than 18 million persons world-wide annually. It is a leading cause of death and so far, only 60% cure rate can be reached within the most developed health care systems. The nature of cancer ...
Immunological studies on anca-associated vasculitis with special reference to T cell activation
(2009-10-16)
This thesis focuses on the role of T cells in ANCA-associated vasculitis. We initially investigated activation markers on T cells in patients with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and renal ...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...
Physiotherapeutic rehabilitation and lumbar fusion surgery
(2010-05-14)
Over the last two decades, the economic costs and rates of lumbar fusion surgery for chronic low back pain has risen dramatically in western industrialized countries. Data from the Swedish National Spine Register suggest ...