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HMBG1 and other soluble factors in HIV-1 pathogenesis
(2009-01-30)
The innate immune system is the first defense mechanism invading
pathogens encounter. Macrophages, dendritic cells and
cytokines/chemokines are important factors for the functionality of the
innate immunity, and provide ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Evaluation of computer-assisted virtual treatment planning and template-guided surgery in dental implant treatment
(2010-05-14)
One of the newly introduced concepts in implant dentistry is computer-guided surgery. The development of 3D implant planning software and imaging technology provide clinicians with 3D information of patients bony structures. ...
Pain-related sodium channels in sensory neurons : gene expression during development and after injury
(2008-05-22)
Pain that goes on over years as a result of nerve damage is an affliction
which disables millions of people worldwide. Chronic injury-induced pain
can become severely debilitating and extremely difficult to treat. ...
Methods in pharmacoepidemiology : four studies, four settings
(2010-04-30)
In the present thesis, four studies using four different settings and
designs are presented in which associations between pharmacological
treatments and possible adverse drug reactions are investigated; some
methodological ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
Toward safety promotion among road users : epidemiology and prevention of road traffic injuries in Iran
(2009-04-29)
Road traffic injuries (RTIs) are a major public health problem. Iran has
one of the highest RTI mortality and morbidity rates in the world. This
thesis aims to contribute understandings on fatal road-user patterns ...
HMGB1 in inflammation : secretion and function
(2008-11-07)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised
by progressive joint destruction. The inflammatory and joint destructive
processes in RA are mediated by resident synovial cells and cells
recruited ...
Eosinophilic dermatosis implications of skin-commensal bacteria and antimicrobial peptides and proteins at birth
(2009-08-28)
At birth, the newborn infant is transferred from a sterile life in utero to an earthly life in coexistence with microbes. This transition includes the potential danger of a microbial invasion through the epithelial linings, ...
Studies on ribonucleotide reductase, a target for anticancer therapy, with focus on electron donor aspects : thioredoxin and glutaredoxin systems
(2009-03-27)
Faithful replication of DNA and its repair are fundamental processes in
all living cells which utilize deoxyribonucleotides as DNA building
blocks. Ribonucleotide reductase (RNR) is the essential enzyme for de
novo ...