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Risk factors for malnutrition after oesophageal cancer surgery
(2008-11-21)
-related quality of life questionnaire (EORTC QLQ-C30) with an oesophageal-specific module (EORTC QLQ-OES18) 6 months and 3 years after surgery. As the four studies were done in different time periods the number of patients differed and the 3 year follow...
Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis
(2008-10-03)
and by dengue IgM ELISA. Only samples collected until day 5 post onset were found positive by PCR: in 73% (35/48) of the samples, dengue RNA of serotypes 1, 2 or 3 was detected. The number of genomes/ml varied between 103 and 108, with a gradual decline over...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
(2010-11-24)
the influence of the genetic variant CYP2C9*3 on the CYP2C9 dependent metabolism of the anti-inflammatory and analgesic drug celecoxib. We found a seven-fold higher median exposure at steady-state in homozygous carriers of the CYP2C9*3 allele compared...
Studies on lipoprotein metabolism and atherogenesis
(2009-03-27)
Atherosclerosis is the primary cause of cardiovascular events such as angina pectoris and myocardial infarction, which together with stroke are responsible for around 50% of all deaths in the United States and Europe. ...
Aspects on latency in HIV-1 infection
(2010-04-16)
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. ...
Experimental studies of N-methyl-D-aspartate receptor NR3 subunits
(2008-04-25)
This thesis focuses on the NR3A and NR3B subunits of the excitatory
glutamate receptor N-methyl-D-aspartate (NMDA). Functional NMDA receptors
are believed to be tetrameric complexes with combinations of NR1 and NR2
subunits, ...
Eosinophilic dermatosis implications of skin-commensal bacteria and antimicrobial peptides and proteins at birth
(2009-08-28)
At birth, the newborn infant is transferred from a sterile life in utero to an earthly life in coexistence with microbes. This transition includes the potential danger of a microbial invasion through the epithelial linings, ...
Role of genes and environment for the development of rheumatoid arthritis : results from the Swedish EIRA study
(2009-01-09)
-environment interaction between HLA-DRB1 SE alleles and smoking; 2. Gene-gene interaction between HLA-DRB1 SE and R620W PTPN22 alleles; 3. Interaction between alcohol consumption, smoking and HLA-DRB1 SE alleles; and 4. Dose dependency between smoking and risk...
Postpartum psychosis and the association with sociodemographic and obstetric factors
(2009-01-30)
Objective: To examine the association between postpartum psychosis and the
sociodemographic factors age, education, marital status and year of
delivery (study 1). To examine the association between neighbourhood
socioeconomic ...