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Epidemiologic and genetic studies of paramyxoviruses
(2008-08-21)
virus (RSV), influenza A virus and parainfluenza virus hMPV was the fourth most common respiratory virus with a detection rate of 2,9% (n=143/4,989) in nasopharyngeal samples. genotype A dominated over genotype B. Approximately 2,6% (n=68/2,579) of the h...
Bystander initiated and dispatcher assisted cardiopulmonary resuscitation in out-of-hospital cardiac arrest
(2009-11-13)
compression only CPR or standard CPR. The primary end point was survival to 30 days. Data were collected between February 2005 to January 2009 for 3 809 patients. The intention-to-treat analysis included 1 276 patients who did meet the inclusion and exclusion...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
Heart rate variability in patients with stable angina pectoris
(2009-01-16)
The rate and modulation of the heart beat (i.e. heart rate variability; HRV) are controlled by the autonomic nervous system. Cardiac sympathetic activation decreases and parasympathetic increases HRV. Measurements of HRV ...
Genetic and functional studies on the thyroid hormone axis
(2008-10-24)
occurring TSAbs-negative Graves disease (n = 11), TSAbs-positive Graves disease (n = 4), hyperfunctioning follicular adenoma (n = 9), nonfunctioning follicular adenoma (n = 5), and toxic (n = 9) or non-toxic multinodular goiter (n =5). The diagnoses were...
Dynamic ultrasonography in neonatal hip instability and acetabular dysplasia
(2008-09-05)
The clinical hip examination, although highly sensitive in expert hands
in detecting neonatal hip instability, can lead to considerable
overtreatment. Ultrasound is increasingly being used to complement the
clinical ...
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
This thesis deals mainly with the synthesis of various sulfur/selenium-containing heterocyclic compounds, many of which include structural features present in several biologically active molecules, with particular emphasis ...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around ...
Experimental combination therapy of brain cancer cell models
(2012-11-21)
Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and ...
Hidradenitis suppurativa : clinical studies with focus on evaluation
(2010-04-02)
Hidradenitis suppurativa (HS) is a chronic inflammatory disease of mainly
unknown aetiology which in most cases involves axillae or groins and that
can last for decades. In this thesis different clinical aspects of HS ...