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Synthetic studies of heterocyclic natural products
(2009-10-23)
The methods that were developed for the synthesis of the heterocyclic natural products luotonin A, ophiuroidine, cephalandole B, and the indol-3-yl-benzoxazinones of cephalandole A are described in this thesis. The ...
Structural maintenance of chromsomes : a complex tale of genomic integrity
(2009-04-03)
Genomic integrity is an absolute requirement for cell survival.
Programmed events such as genome rearrangements and DNA replication can
cause lesions in the DNA, as can exogenous agents such as radiation and
chemicals. ...
CD8alpha/alpha+ T-cells and immune memory
(2009-04-29)
A better understanding of T-cell memory formation is crucial for rationale vaccine design and the identification of correlates of immune protection. The CD8αα homodimer expressed on CD8+ T-cells is not anymore considered ...
Transcription factor control in neuronal maintenance and survival
(2010-04-16)
The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain ...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Infections and infectious related morbidity during pregnancy : short and long-term effects
(2008-11-28)
The aim of this thesis was to elucidate the association between
infections during pregnancy and risks of miscarriage, preterm delivery
and later development of autism.
We identified 60 755 women with singleton ...
Studies of membrane-binding proteins involved in synaptic vesicle recycling
(2009-03-27)
Signaling between neurons occurs at synapses. A presynaptic nerve
terminal releases neurotransmitter, which diffuses over the synaptic
cleft, and binds to postsynaptic receptors. Release occurs by fusion of
neurotrans ...
Development of novel DNA vaccine and immunotherapeutic approaches
(2009-08-06)
. Our data provide evidence in support of the theory that Btk negatively regulates both TLR9 activation and expression in mouse splenic B cells. Thus, down regulation of Btk with plasmid expressing short hairpin RNA (shRNA) and attaching TLR9 ligands...
In silico analysis of pathways targeted by EBV infection and malignant transformation
(2009-10-23)
Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus with dual cell tropism for human B-lymphocytes and epithelial cells. EBV infection is linked to several malignancies such as Burkitt s lymphoma (BL) and nasopharyngeal ...
Structural enzymology of dormancy related proteins from Mycobacterium tuberculosis
(2009-01-09)
Mycobacterium tuberculosis, the causative agent of tuberculosis, is one of the most lethal infectious agents affecting humans. The World Health Organisation estimates that about one-third of the world s population is ...