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Injury profile and injury risk factors in junior tennis players
(2010-05-28)
-nine players sustained totally 100 new and recurrent injuries, 73 injuries in boys and 27 injuries in girls. Injury incidence for both genders was 2.3 injuries/1000 hours of tennis playing time, for boys 1.7 injuries/1000 hours and for girls 0.6 injuries/1000...
Studies on ribonucleotide reductase, a target for anticancer therapy, with focus on electron donor aspects : thioredoxin and glutaredoxin systems
(2009-03-27)
Faithful replication of DNA and its repair are fundamental processes in
all living cells which utilize deoxyribonucleotides as DNA building
blocks. Ribonucleotide reductase (RNR) is the essential enzyme for de
novo ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
A new technique to assess dermal absorption of chemical vapor in vitro by thermogravimetric analysis (TGA)
(2008-11-28)
vapor (from water, 2-propanol, methanol and toluene). When no chemical vapor was present the weight of the skin was constant and upon addition of chemical vapor the weight of the skin increased until an equilibrium with the surrounding air was reached...
Spread and distribution of drug resistance and compensatory mutations in Plasmodium falciparum
(2012-05-08)
and recently a putative H+ pump (pfvp2) has been suggested to be linked to CQ resistant P. falciparum. The aim of this thesis was to identify resistance associated genetic polymorphisms in P. falciparum and P.vivax from Honduras and to describe the worldwide...
The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily ...
Immunological studies on anca-associated vasculitis with special reference to T cell activation
(2009-10-16)
This thesis focuses on the role of T cells in ANCA-associated vasculitis. We initially investigated activation markers on T cells in patients with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and renal ...
Synthetic pulmonary surfactant : effects of surfactant proteins B and C and their analogues
(2010-08-19)
Pulmonary surfactant is a lipid/protein mixture lining the air-liquid
interface in the alveoli. Its main function is to lower surface tension
during respiration and thereby prevent alveolar collapse at
end-expiration. ...
Recurrent laryngeal nerve injury
(2008-09-05)
Injury to the recurrent laryngeal nerve is accompanied by a poor functional recovery of the target organ, the larynx. For the patient this means impairments of vocal fold mobility and various kinds of voice disorders. In ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...