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The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells
(2008-09-04)
The tumor suppressor p53 is a critical regulator of life and death in
cells. The p53 protein is present at very low levels in cells under
normal conditions but accumulates in response to different stress
stimuli, such ...
A new computed tomography method for evaluation of orthopedic implants : applied to the acetabular cup
(2009-12-25)
Background: Two major long term complications after total hip
arthroplasty (THA) is aseptic loosening and wear of the implant. In the
clinical situation a detection level of approximately 1 mm is desirable.
However, ...
Tobacco smoking, high body mass index and the outcome after surgery : the role of intervention
(2008-11-07)
The negative effects of smoking and obesity on public health are
well-known. Despite this knowledge, the smoking-attributable morbidity
and mortality is estimated to rise rapidly in the forthcoming years, and
obesity ...
Regulation of Hedgehog signalling during development and carcinogenesis
(2009-11-26)
commonly arises due to mutations in the gene sequence of the Hh receptor protein PATCHED1 (PTCH1). The PTCH1 gene is reported to have four first exons and we showed in paper I that PTCH1 is transcriptionally regulated by three independent promoters...
Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
release. Using SUR1(-/-) mice, we unambiguously confirmed the previous notion that the insulinotropic activity of BL11282 is unrelated to its interaction with ATPdependent K+ channels. We have also shown that previously described targets for imidazoline...
The impact of tobacco use on postoperative complications
(2008-08-29)
of postoperative complications after inguinal hernia surgery (OR 1.34; 95% CI 1.04 1.72) and after appendectomy due to non-perforated appendicitis (RR 1.51; 95% CI 1.03 2.22). Smoking was also significantly associated with an increased risk of perforated...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
Exploring a national practice-based register for the management of rheumatoid arthritis
(2008-10-17)
Rheumatoid arthritis (RA) is a chronic, inflammatory, auto-immune disease with an unpredictable and debilitating course. From diagnosis and onward, RA patients who need treatment with anti-rheumatic drugs will require ...
HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation
(2008-12-26)
Currently, big efforts in HIV-1 research are devoted to the design of a
HIV-1 vaccine. However, no successful vaccine is yet available, also due
to the lack of basic knowledge in HIV-1 pathogenesis which is still
profound. ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
in C-section eosinophils compared to normal delivery eosinophils, here, being IFN-gamma receptor and STAT1. Our RT-PCR data confirms the upregulation of these genes in eosinophils from cord blood compared to normal delivery. This indicates a more...