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Causal inference in epidemiological research
(2009-01-16)
Traditionally, statistics has been viewed as the branch of science which
deals with association. Many epidemiological research questions, however,
are concerned with causation, not association. In this thesis we ...
Structural maintenance of chromsomes : a complex tale of genomic integrity
(2009-04-03)
Genomic integrity is an absolute requirement for cell survival.
Programmed events such as genome rearrangements and DNA replication can
cause lesions in the DNA, as can exogenous agents such as radiation and
chemicals. ...
Epidemiological and recovery facilitating studies of an urban population of stroke patients in Iran
(2010-05-28)
%, and smoking in 20%. Interventional studies: Motor function and ADL were recovered for all participants during treatment and at 6-month follow-up. There were slight but significant differences in BI and NIHSS compared to placebo at the 6 month follow-up. Mood...
Looking for arthritis regulating genes on mouse chromosome 6 & 14
(2008-11-05)
Rheumatoid arthritis (RA) is a chronic autoimmune disease of the joints with a complex aetiology affected by largely unknown genetic and environmental factors. Since ~60% of susceptibility to RA is genetically inherited, ...
Role of water channels in kidney and lung
(2009-11-27)
Aquaporins (AQPs) are membrane proteins that function as water channels facilitating a rapid and regulated transport of water across cell membranes. AQPs in kidney and lung play pivotal roles for the regulation of water ...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Cat allergy : diagnosis and characterization of important allergens
(2008-05-09)
Allergy affects about 25% of the population. Allergic diseases are
manifested in many ways, from mild rhinitis to life-threatening
anaphylaxis. Globally, more than 15% of children and adults are allergic
to pets.
The ...
Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
11282 stimulated insulin secretion. Indeed, expression of dominant negative cAMP-GEFII and Rim2 mutant proteins in MIN6 cells lead to a significant reduction in insulin secretion stimulated by the imidazoline. To further investigate this direct mechanism...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...
Experimental combination therapy of brain cancer cell models
(2012-11-21)
Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and ...