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Sexual life after childbirth and aspects of midwives’ counselling at the postnatal check-up
(2009-02-27)
The overall aim of this thesis was to explore and describe how sexual
life after childbirth is communicated, addressed and reflected upon among
new mothers, fathers and midwives and the impact of leaving first and
minor ...
HIV-1 genotype and vertical transmission in northern Vietnam
(2008-10-28)
After 18 years from the beginning of the HIV-1/AIDS epidemic in Vietnam, the number of HIV-1 infected individuals is still increasing. Investigations conducted at two distinct time points in two separate groups of HIV-1 infected intravenous drug...
Epigenic regulation and posttranslational modification of human cytochrome P450s : focus on CYP2W1, CYP1A2 and CYP2C18
(2008-11-21)
The cytochrome P450 superfamily represents a very important group of
enzymes that are responsible for the metabolism of drugs as well as of
endogenous compounds. Many P450s are genetically polymorphic causing
important ...
Transcription factor control in neuronal maintenance and survival
(2010-04-16)
The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain dopamine (mDA) neurons...
Adhesion molecules and synapse remodeling during motoneuron regeneration
(2009-10-09)
resulted in altered expression of SynCAM3/necl-1 and SynCAM4/necl-4 in the nerve, which indicates possible involvement of these molecules in remyelination. SynCAM1/necl-2, SynCAM2/necl-3, and neuroligin (NLG) -2 and -3 were expressed by unlesioned...
Microsomal glutathione transferase 1 in anti-cancer drug resistance and protection against oxidative stress
(2010-03-05)
glutathione transferase 1 (MGST1) is a membrane protein located in the endoplasmic reticulum and the outer membrane of mitochondria. MGST1 is involved in the direct conjugation of glutathione to endogenous and exogenous toxic electrophilic hydrophobic...
Statistical methods for biomarker discovery in proteomics
(2008-08-15)
Surface-Enhanced Laser Desorption and Ionization (SELDI) is a promising proteomic technique for discovering biomarkers. However, the pre-processing of the raw data is still problematic. Integrating transcriptomic and ...
Danger within : HMGB1 as a mediator of arthritis
(2008-10-31)
Chronic arthritis occurs in childhood as juvenile idiopathic arthritis and in adults most commonly as rheumatoid arthritis. The clinical expression of these diseases differ and it is presently unknown to what extent they ...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
lipoprotein receptor-related protein (LRP)/CD91. Interaction of TSP-1 with its cell surface receptors calreticulin (CRT), LRP and integrin associated protein (IAP)/CD47 was promoting motility of T cells in 3D collagen through CD47. T cell surface TSP-1 also...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
dihydropyrazolone, namely 4-cyano-1-cyanoacetyl-2-(cyclohexen-1-yl)-1,2-diazaspiro[4.5]decan-3-one, whose structure was confirmed by an X-ray analysis. Mild hydrolysis of this compound resulted in isolation of a des-cyanoacetylated product. In addition, prolonged...