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CD8alpha/alpha+ T-cells and immune memory
(2009-04-29)
A better understanding of T-cell memory formation is crucial for rationale vaccine design and the identification of correlates of immune protection. The CD8αα homodimer expressed on CD8+ T-cells is not anymore considered to represent a TCR co...
Causal inference in epidemiological research
(2009-01-16)
Traditionally, statistics has been viewed as the branch of science which
deals with association. Many epidemiological research questions, however,
are concerned with causation, not association. In this thesis we ...
Teleost retina : a model to study neurogenesis and angiogenesis
(2009-03-09)
Teleost models, zebrafish and medaka have become popular models to study
various aspects of developmental biology and genetics. The rapid
embryonic development, transparent embryos and the availability of many
mutants ...
Role of genes and environment for the development of rheumatoid arthritis : results from the Swedish EIRA study
(2009-01-09)
Rheumatoid arthritis (RA) is a complex disease with autoimmune features primarily causing destruction in the joints of the body. Knowledge regarding risk indicators and causes are increasing but so far only a few genetic ...
New apheresis techniques in transplantation
(2008-11-21)
The shortage of organs for transplantation is a global problem and therefore it is of outmost importance to increase the number of donations and improve long term graft survival. As an effort to increase kidney donations, ...
Ultrastructural studies of the blood-urine barrier in proteinuric states
(2010-04-30)
The kidneys filter enormous amounts of blood every day, removing excess fluid and waste products while retaining cells and large proteins in the circulation. The podocytes with their foot processes and slit diaphragms (SD) ...
Chest wall sarcomas
(2010-03-05)
Aim: To evaluate initial symptoms and clinical features, diagnosis and delay
in osteosarcoma (OS), Ewing sarcoma (EWS) and chest wall chondrosarcoma
(CS). To assess treatment and identify prognostic factors in chest ...
Cardiovascular disease prevention after spinal cord injury : a new challenge
(2010-05-07)
Spinal cord injury (SCI) typically leads to permanent infralesional motor
and sensory functional losses, pathophysiological aberrations in most
organ systems and a lasting vulnerability for a variety of complicating
conditions. ...
Self-esteem, sense of coherence and attention deficit hyperactivity disorder : a longitudinal study from childhood to adulthood
(2009-10-23)
contacted in four different waves. Wave 1 was in 1994 (twins were 8-9 years old) and wave 2 was in 1999 (twins were 13-14 years old). In 2001, a clinical study with a sub sample including the twin pairs living in the Stockholm county area (twins were 15...
Influence of renal dysfunction on therapy and prognosis in patients with myocardial infarction
(2010-04-30)
The aim of this thesis is to evaluate the influence of renal dysfunction on the presentation for myocardial infarction (MI), its treatment and outcome. Patients between 2003 and 2006 were selected from the nationwide Swedish ...