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Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis
(2008-10-03)
and by dengue IgM ELISA. Only samples collected until day 5 post onset were found positive by PCR: in 73% (35/48) of the samples, dengue RNA of serotypes 1, 2 or 3 was detected. The number of genomes/ml varied between 103 and 108, with a gradual decline over...
The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Teleost retina : a model to study neurogenesis and angiogenesis
(2009-03-09)
Teleost models, zebrafish and medaka have become popular models to study
various aspects of developmental biology and genetics. The rapid
embryonic development, transparent embryos and the availability of many
mutants ...
Biomarkers of suicide risk in psychosis
(2009-11-27)
was to investigate the long-term suicide risk in schizophrenia spectrum psychosis, whether concentrations of the CSF monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) are related to suicidal behavior and to the overall mortality...
Brain volume reduction over four decades in multiple sclerosis
(2010-05-07)
Introduction: Multiple sclerosis (MS) is a common neurological disease causing intermittent or cumulative disability, predominantly among women of child-bearing age. MS is a chronic inflammatory disease of the central ...
Epidemiological and recovery facilitating studies of an urban population of stroke patients in Iran
(2010-05-28)
Introduction: Approximately 15 million people have a stroke annually in the world, of whom one third will die within one year and one third will suffer permanent disability. Over 85% of these deaths happen in people living ...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
dihydropyrazolone, namely 4-cyano-1-cyanoacetyl-2-(cyclohexen-1-yl)-1,2-diazaspiro[4.5]decan-3-one, whose structure was confirmed by an X-ray analysis. Mild hydrolysis of this compound resulted in isolation of a des-cyanoacetylated product. In addition, prolonged...
Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
A longitudinal study of dentofacial morphology in young children treated for the obstructive sleep apnoea syndrome
(2008-09-19)
with tonsillectomy and/or adenoidectomy. Presurgically the OSAS children underwent clinical examination by an otolaryngologist, sleep registration with polysomnography (PSG), and orthodontic examination. Follow-up examinations and registrations were made 1, 3, and 5...