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Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
between Env immunogens and CD4-expressing cells would negatively affect the elicitation of Envspecific immune responses, CD4 binding-competent and CD4 binding-defective trimers were constructed and inoculated into non-human primates. No difference...
Teleost retina : a model to study neurogenesis and angiogenesis
(2009-03-09)
Teleost models, zebrafish and medaka have become popular models to study
various aspects of developmental biology and genetics. The rapid
embryonic development, transparent embryos and the availability of many
mutants ...
Prevention of mother-to-child transmission of HIV-1 using antiretroviral drugs in Dar Es Salaam, Tanzania
(2009-08-21)
, respectively and the RR for HIV infection or death compared to placebo were 0.39, 0.64 and 0.97, respectively. After 18 months of follow up the transmission rates were 14.9% (95%CI 9.4-22.8), 18.1% (12.1-26.2), 20.0% (12.9-30.1) and 22.2% (15.9-30.2) for groups...
Manipulating neural stem cells
(2010-03-17)
one factor, Oct4. In manuscript IV Oct4 expression is chemically induced. Endogenous expression of the pluripotency factors Nanog and Rex1 were measured to investigate whether Oct4-inducing conditions could lead to a reprogrammed state....
Studies on leukotriene B4 and alarmins in inflammatory responses
(2010-01-29)
Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial polypeptides, which belong...
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
analogues such as 1-sila-, 1-germa- and 1-selenacyclohepta-2,4,6-trienes containing two fused aromatic or heterocyclic units....
Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1
(2009-03-27)
and with histones, and that the p300-MAML1 complex specifically acetylates the tails of histones H3 and H4. Furthermore, we showed that MAML1 is acetylated by p300, and identified conserved lysines in the MAML1 N-terminus as the target for p300 acetylation. We found...
Studies on arterial endothelial function and intima-media thickness using ultrasound technique
(2008-05-09)
Background: The development of ultrasonographic arterial imaging, high-resolution B-mode ultrasonography, has created a technical basis for a new diagnostic approach to atherosclerotic disease by offering the possibility ...
Mitochondrial function adaptations to changed metabolic conditions
(2010-09-09)
at hypoxia was compared to equivalent normoxic training, performed at the same relative intensity. Eight untrained volunteers performed one-legged cycle training during 4 weeks. Muscle biopsies were taken before and after the exercise period. The leg trained...
Studies on cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in lymphomas
(2008-08-22)
Classical Hodgkin lymphoma (cHL) is a malignant disorder with striking
inflammatory features. Since cysteinyl leukotrienes (cysLTs) are potent
inflammatory mediators it was of interest to study their potential role
in ...