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Genetic analysis of type 1 diabetes susceptibilty
(2008-11-21)
Type 1 diabetes (T1D) is a multifactorial disease where the pancreatic beta-cells are destroyed in an autoimmune attack. For the patients, this in turn leads to lifelong daily insulin treatment and increased risk for various kinds of complications...
HMBG1 and other soluble factors in HIV-1 pathogenesis
(2009-01-30)
The innate immune system is the first defense mechanism invading
pathogens encounter. Macrophages, dendritic cells and
cytokines/chemokines are important factors for the functionality of the
innate immunity, and provide ...
Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1
(2009-03-27)
MAML1 was first identified as a coactivator for Notch receptors, but later it was also found to function as a coactivator for several other activators, including p53, beta-catenin, and MEF2C. MAML1 is critical for Notch signalling and has been shown...
The effects of endothelin-1 in human adipose tissue
(2010-04-26)
tissue and thus endothelial cells are present. They release the vascular peptide endothelin-1 (ET-1), an extremely potent vasoconstrictor involved in the regulation of blood pressure but also a multifunctional peptide with cytokine-like activity that can...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, elucidating the function of DJ...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
the protein domains and the glycosaminoglycan chains can contribute to the functions of syndecans. Syndecans are involved in many cellular processes including cell differentiation, proliferation, adhesion and migration. Syndecan-1 is the prototype and a hybrid...
Aspects on latency in HIV-1 infection
(2010-04-16)
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. Unfortunately, ART does...
Transcription factor control in neuronal maintenance and survival
(2010-04-16)
The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain dopamine (mDA) neurons...
Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis
(2008-10-03)
Dengue fever (DF) is the most common global viral mosquito-borne infection, with 100 million estimated cases annually in tropical and subtropical areas. The dengue viruses (genus Flavivirus, Flaviviridae) occur in 4 serotypes (DENV-1 to DENV-4...
Regulation of Hedgehog signalling during development and carcinogenesis
(2009-11-26)
commonly arises due to mutations in the gene sequence of the Hh receptor protein PATCHED1 (PTCH1). The PTCH1 gene is reported to have four first exons and we showed in paper I that PTCH1 is transcriptionally regulated by three independent promoters...